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Is One Vaccine Dose Size Right For All Dogs If you would like to read some sad experiences of people who have contacted me about this problem, go here. Ron. Hines DVM Ph. D Lots of my articles are plagiarized and altered on the web to market. There are never ads running or anything. Try to stay. with the ones that begin with http www. URL box or find all my articles at ACC. This is a difficult article for most of the people for whom I write my articles. It is long winded and technical. If any of it is unclear, send me an email and I will do my best to explain it September of 2. Two dog owners wrote to me expressing their grief at loosing their pets subsequent to having received leptospirosis vaccine boosters. Veterinarians know that lepto vaccines are the most likely products to give vaccine reactions ref   It troubled me that they asked questions that I could not answer. While that was still on my mind, my veterinary newsletter ran a clip about a Connecticut veterinarians legal predicament for scaling vaccine dose to his patients body weight. Later that month, I saw an AVMA quote from a Department of Agricultures vaccine regulator describing vaccine manufacturers as his clients. How strange I had thought pet owners and practicing veterinarians were the clients of the CVB It seemed to me that the time had come to have a closer look at the whole situation. The East Coast dog had received Merials Recombitek 4. LEPTO. So I called the Merial veterinarians hotline. The nice young veterinarian who answered seemed to know little more about the subject of vaccine reactions than I did. The vaccine safety studies she promised to send me never arrived. The second dog belonged to a servicewoman stationed in Japan. It had received Mercks Nobivac Lepto 4 vaccine. My attempts at obtaining vaccine reaction data on that product were equally unsuccessful. So I called the veterinarians inquiry line at the Center For Veterinary Biologics CVB in Ames, Iowa. Their Biologics Specialist, a Ph. D in Molecular Biology, was uninformative. Not only would he not discuss vaccine reactions with me, he told me that all adverse event bad reaction reports the CVB receives from the public and veterinarians alike become proprietary property of the vaccine manufacturers and I could not see them. So I asked to view the initial safety studies submitted to the CVB when the vaccines were initially approved. He refused that as well and chuckled that any attempts I might make to obtain any additional information under The Freedom of Information Act would be unsuccessful as well. A flashback to when my children were young and wouldnt show me what they were hiding in their hands behind their back. Dog owners like you are in a unique situation when it comes to your pets vaccine safety and efficacy. Although all human vaccines are reviewed for safety and efficacy by the FDA animal vaccines are reviewed by the US Department of agriculture under an archaic law, The Virus Serum and Toxin Act of 1. You can see all bad reaction reports on the vaccines you take anytime they are posted online. But you are not allowed to see the same information when it comes to your pet. I could see I had quite a project on my hands if I wanted to understand the nature and depth of the problem and that it would require examining many facets of the situation. Over the years, the veterinary establishment has developed a rather inflexible, pyramidal structure much like the old monarchies of Europe. Their official position is that vaccine dose has nothing to do with bad adverse event reactions. The one size fits all vaccine dogma reigns supreme and it is considered blasphemy by many to question it. I had plenty of projects on my to do list and wasnt thrilled to have another besides, I have enough problems with institutionalized veterinary medicine already ref but the medical student kept asking me questions I could not answer. So I decided I would write an email to the most knowledgeable person I knew of regarding vaccines, Dr. Stanley Plotkin, I would let his response govern my course. Dr. Plotkin speedily replied  that my perception that there were no studies that specifically addressed that question on dose to body weight effects were correct. In the discussion that follows, I sometimes use the word vaccine and antigen its active ingredient interchangeably. When I say antigen mass I mean the amount of vaccine. But although the primary ingredient in all vaccines is antigen, many vaccines contain other ingredient, either required in their manufacture like blood extracts BSA or things added to increase the products ability to stimulate the immune system adjuvants. There are 7 leptospirosis containing vaccines currently on the market in the United States ref All but one combine the leptospirosis part dead antigen with attenuated weakened live virus modified live virus or MLV designed to protect your dog against a variety of other common canine diseases. How dead inactivated antigen and live MLV react within your pets body are quite different. So do not assume that anything I have to say about killed antigen dynamics has anything to do with how they might react to MLV vaccines. In the case of MLV vaccines, like distemper or parvovirus vaccine, only enough organisms antigen mass need be given to assure that they multiply in your pets body and that the resulting very mild infection produces protective antibodies and immunological memory that guard your pet into the future. In the second type killed antigen vaccinesbacterins like leptospirosis, Lyme or rabies vaccine, we count on the mass the quantity of dead antigens to produce the antibodies and memory that will protect your pet into the future. What Happens After My Pet Receives His Leptospirosis Vaccination Within an hour or so of receiving the shot, the antigens in the vaccine will be carried through your pets lymphatic vessels to the nearest lymph nodes they drain to. The courier cells that carry the antigens are dendritic cells, sentinel guarding cells of your pets immune system scattered throughout its body. They are particularly common under the surface of your dogs skin, nose, lungs and intestine the places invading bacteria and virus are most likely to enter its body. Dendritic cells deliver present the vaccine antigen to another type of lymph node cell, the virgin naive T cells CD4 T cells, with orders to begin dividing and to produce peptides and combine them with MHCII molecules. The peptide MHCII complexes will stimulate your pets CD4 T cells to divide proliferate to their Th. Others will become cells Tfh or T folicle helper cells that assist certain B cells plasma cells in your pets lymph nodes in producing antibodies against the vaccine antigens that were injected. If this choreographed dance of the cells does not go precisely as ordered, your pet will not become immune or your pet will produce antibodies that are not in the best interests of its health. If your smaller dog gets a whopping dose of antigen, more than can be processed opsonized in those regional lymph nodes, what becomes of the excess is anyones guess. Throughout the process, memory cells B and Ttypes are also created cells that will begin the process again in a more rapid fashion if an antigen similar to the one in your pets vaccine ever enters its body again. Some of those cells live a very long time. Those cells are the reason your dog will never become ill with parvo once a single effective vaccine dose against parvo gets properly processed. Other antigens, like the antigens that leptospirosis produce LPS or surface lipopolysaccharides, do not produce as good immunological memory. Those are the ones that require your veterinarian to periodically remind the pets immune system with a booster vaccination. CIA, ISIS, Mossad False Flag Another. As More Americans Slaughtered For The Agenda Lee Harvey Paddock Was Dressed Up With Guns But No Motive Never Knew He Was Patsied Weve Been Covering This Since 1 4. AM Right After Massacre My Very First Headline Title Has NOT Needed Updating. ISIS Mass Terror Attack In Las Vegas. Trump Is Lying. ALL AMERICANS MUST WATCH THIS VIDEOWoman Survives Massacre Unhurt. Reveals Multiple Shooters. And Then Is Found Dead In Her BedroomIt. Was A Terrorist Attack. Group Organized. Choreographed. 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